Application US20210113831

SYSTEMS, METHODS, AND DEVICES FOR BRAIN STIMULATION AND MONITORING
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US20210113831

1. A method comprising: (2) (3)

obtaining a plurality of measurements from a brain of a user via an interface, wherein the plurality of measurements includes indications of slow wave oscillations and sleep spindles;

generating, via a processing device, a plurality of brain state parameters characterizing one or more features of at least one brain state of the brain of the user, wherein the plurality of brain state parameters includes an indication of a synchrony pattern between the measured slow wave oscillations and the measured sleep spindles including an assessment of a temporal directionality of interactions between the measured slow wave oscillations and sleep spindles and an amount of temporal deviation between slow wave oscillation peaks and sleep spindle peaks; and

transmitting one or more control signals from a controller to the interface to apply one or more stimuli to cortical tissue of the brain, wherein the one or more stimuli is configured to enhance synchrony of slow wave oscillations and sleep spindles such that sleep spindle peaks occur closer to slow wave oscillation peaks.

2. The method of claim 1, further comprising, via the processing device, (3) (2)

generating a model of the brain of the user based, at least in part, on the plurality of measurements and the synchrony pattern, and

determining, using the model and training data comprising one or more mediation data points, a procedure for mediation specifying at least an amplitude or a duration of stimuli to be applied to the brain to adjust a power of slow wave oscillations, wherein the one or more control signals are generated by the controller based on the procedure for mediation.

3. The method of claim 2 further comprising: (0) (4)

obtaining a plurality of subsequent measurements from the brain via the interface, wherein the plurality of subsequent measurements are obtained after the one or more stimuli is applied to the brain;

determining, via the processing device, changes to the plurality of brain state parameters based on the plurality of subsequent measurements;

modifying, via the processing device, the procedure for mediation based on the changes to the plurality of brain state parameters, wherein the procedure for mediation is updated using the model; and

adjusting, via the processing device, the model based on the one or more control signals and the plurality of subsequent measurements.

4. The method of claim 2, wherein the one or more stimuli is configured to increase the power of slow wave oscillations of the brain to enhance synchrony of slow wave oscillation peaks and sleep spindle peaks. (0)

5. The method of claim 2, further comprising providing the procedure for mediation to one or more entities. (1) (0)

7. The method of claim 1, wherein the at least one brain state includes an unconscious state corresponding to non-rapid-eye-movement sleep. (0)

8. A system comprising: (2) (3)

an interface configured to obtain a plurality of measurements from a brain of a user, wherein the plurality of measurements includes indications of slow wave oscillations and sleep spindles;

a processing device configured to generate a plurality of brain state parameters characterizing one or more features of at least one brain state of the brain of the user, wherein the brain state parameters include an indication of a synchrony pattern between the measured slow wave oscillations and the measured sleep spindles including an assessment of a temporal directionality of interactions between the measured slow wave oscillations and sleep spindles and an amount of temporal deviation between slow wave oscillation peaks and sleep spindle peaks; and

a controller configured to transmit one or more control signals to apply one or more stimuli to cortical tissue of the brain, wherein the one or more stimuli is configured to enhance synchrony of slow wave oscillations and sleep spindles such that sleep spindle peaks occur closer to slow wave oscillation peaks.

9. The system of claim 8, wherein the processing device is further configured: (3) (2)

generate a model of the brain of the user based, at least in part, on the plurality of measurements and the synchrony pattern, and

determine, using the model and training data comprising one or more mediation data points, a procedure for mediation specifying at least an amplitude or a duration of stimuli to be applied to the brain to adjust a power of slow wave oscillations, wherein the one or more control signals are generated by the controller based on the procedure for mediation.

10. The system of claim 9, (0) (2)

11. The system of claim 9, wherein the one or more stimuli is configured to increase the power of slow wave oscillations of the brain to enhance synchrony of slow wave oscillation peaks and sleep spindle peaks. (0)

12. The system of claim 9, wherein the processing device is further configured to provide the procedure for mediation to one or more entities. (1) (0)

14. The system of claim 8, wherein the at least one brain state includes an unconscious state corresponding to non-rapid-eye-movement sleep. (0)

15. A non-transitory computer readable medium storing one or more programs configured for execution by a computer, the one or more programs comprising instructions for: (2) (3)

obtaining a plurality of measurements from a brain of a user via an interface, wherein the plurality of measurements includes indications of slow wave oscillations and sleep spindles;

16. The non-transitory computer readable medium of claim 15, wherein the one or more programs further comprise instructions for, via the processing device, (3) (2)

generating a model of the brain of the user based, at least in part, on the plurality of measurements and the synchrony pattern, and

17. The non-transitory computer readable medium of claim 16, wherein the one or more programs further comprise instructions for: (0) (4)

obtaining a plurality of subsequent measurements from the brain via the interface, wherein the plurality of subsequent measurements are obtained after the one or more stimuli is applied to the brain;

determining, via the processing device, changes to the plurality of brain state parameters based on the plurality of subsequent measurements;

modifying, via the processing device, the procedure for mediation based on the changes to the plurality of brain state parameters, wherein the procedure for mediation is updated using the model; and

adjusting, via the processing device, the model based on the one or more control signals and the plurality of subsequent measurements.

18. The non-transitory computer readable medium of claim 16, wherein the one or more stimuli is configured to increase the power of slow wave oscillations of the brain to enhance synchrony of slow wave oscillation peaks and sleep spindle peaks. (0)

19. The non-transitory computer readable medium of claim 16, wherein the one or more programs further comprise instructions for: providing the procedure for mediation to one or more entities. (0)

20. The non-transitory computer readable medium of claim 15, wherein the at least one brain state includes an unconscious state corresponding to non-rapid-eye-movement sleep. (0)

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Application US20210113831

SYSTEMS, METHODS, AND DEVICES FOR BRAIN STIMULATION AND MONITORING

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