Application US20200155790

SYSTEMS AND METHODS FOR TRANSDERMAL ELECTRICAL STIMULATION TO IMPROVE SLEEP
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US20200155790

1. A method of non-invasively reducing sleep onset and increasing sleep duration, the method comprising: (18) (3)

attaching a first electrode to a subject's head or neck at a first location and a second electrode to the subject's head or neck at a second location, wherein the first and the second electrode are coupled to a transdermal electrical stimulation (TES) applicator worn by the subject;

applying an electrical stimulation between the first and second electrodes, wherein the electrical stimulation has a peak amplitude of greater than 3 mA, a frequency of greater than 250 Hz, and a duty cycle of greater than 10%; and

continuing application of the electrical stimulation for a stimulation duration of at least one minutes to enhance sleepiness, sustain sleep or to enhance sleepiness and sustain sleep.

2. The method of claim 1, wherein attaching comprises adhesively attaching. (0)

3. The method of claim 1, wherein attaching comprises attaching the first electrode to the subject's temple region. (0)

4. The method of claim 1, wherein attaching comprises attaching the second electrode to the subject's neck above the subject's vertebra prominens. (0)

5. The method of claim 1, further comprising allowing the subject to select a set of parameter for the electrical stimulation to be applied, wherein the set of parameters includes one or more of: stimulation duration, frequency, peak amplitude, and duty cycle. (0)

6. The method of claim 1, further comprising wearing the electrodes while the subject sleeps. (0)

7. The method of claim 1, further comprising removing the first and second electrodes and TES applicator prior to the subject sleeping. (0)

8. The method of claim 1, wherein applying comprises applying a biphasic electrical stimulation. (0)

9. The method of claim 1, wherein applying comprises applying a biphasic electrical stimulation and further wherein the biphasic electrical stimulation is asymmetric with respect to positive and negative going phases. (0)

10. The method of claim 1, wherein applying comprises applying the electrical stimulation having a duty cycle of between 10% and 90%. (0)

11. The method of claim 1, wherein applying comprises applying the electrical stimulation having a duty cycle of between 30% and 60%. (0)

12. The method of claim 1, wherein applying comprises applying the electrical stimulation having a peak amplitude of 5 mA or greater. (0)

13. The method of claim 1, wherein applying comprises applying the electrical stimulation having a frequency of greater than 500 Hz. (0)

14. The method of claim 1, wherein applying comprises applying the electrical stimulation having a frequency of greater than 750 Hz. (0)

15. The method of claim 1, wherein applying comprises applying the electrical stimulation having a frequency of greater than 5 kHz. (0)

16. The method of claim 1, wherein continuing application of the electrical stimulation for a stimulation duration comprises continuing for a stimulation duration of at least five minutes. (0)

17. The method of claim 1, wherein applying comprises applying the electrical stimulation having amplitude modulation. (0)

18. The method of claim 1, wherein applying comprises applying the electrical stimulation having amplitude modulation, and further wherein the amplitude modulation has a frequency of less than 250 Hz. (0)

19. The method of claim 1, wherein applying comprises applying the electrical stimulation having a burst mode. (0)

20. A method of non-invasively reducing sleep onset, the method comprising: (0) (3)

placing a first electrode of a wearable transdermal electrical stimulation (TES) applicator on a subject's temple region and a second electrode on a back of the subject's neck;

activating the wearable TES applicator to deliver a biphasic electrical stimulation between the first and second electrodes having a duty cycle of greater than 10 percent, a frequency of 250 Hz or greater, and an intensity of 3 mA or greater, wherein the biphasic electrical stimulation is asymmetric with respect to positive and negative going phases; and

reducing sleep onset by applying the biphasic electrical stimulation between the first and second electrodes for 10 seconds or longer.

21. A method of non-invasively inducing sleep in a subject, the method comprising: (0) (3)

placing a first electrode of a wearable transdermal electrical stimulation (TES) applicator on the subject's skin on the subject's temple region and a second electrode on a back of the subject's neck above a vertebra prominens;

activating the wearable TES applicator to deliver a biphasic electrical stimulation having a duty cycle of greater than 10 percent, a frequency of 250 Hz or greater, and an intensity of 3 mA or greater, wherein the biphasic electrical stimulation is asymmetric with respect to positive and negative going phases; and

inducing sleep by applying the biphasic electrical stimulation between the first and the second electrodes for 10 seconds or longer.

22. A method of maintaining sleep in a subject, the method comprising: (0) (3)

maintaining a state of sleep in the subject by applying the biphasic electrical stimulation between the first and second electrodes for 10 seconds or longer while the subject is asleep.

23-80. (canceled). (0)

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Application US20200155790

SYSTEMS AND METHODS FOR TRANSDERMAL ELECTRICAL STIMULATION TO IMPROVE SLEEP

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