Application US20190142271

Systems, Devices, Components and Methods for Detecting the Locations of Sources of Cardiac Rhythm Disorders in a Patient's Heart
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US20190142271

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77. A method of detecting a location of a source of at least one cardiac rhythm disorder in a patient's heart using at least one computing device and a display operably connected thereto, where the at least one computing device comprises at least one non-transitory computer readable medium configured to store instructions executable by at least one processor for determining the source and location of the cardiac rhythm disorder in the patient's heart, the method comprising: (15) (6)

(a) receiving electrogram signals from an array of electrodes positioned in or on a patient;

(b) normalizing and/or adjusting amplitudes of the electrogram signals in the data acquisition device;

(c) assigning predetermined spatial or areal positions of electrodes to the electrodes and their corresponding electrogram signals in the computing device;

(d) for each or selected discrete times over which the electrogram signals are being processed, processing the amplitude-adjusted electrogram signals in the computing device to generate a plurality of three-dimensional electrogram surfaces or data sets corresponding at least partially to the electrode positions, one surface or data set being generated for each such time;

(e) processing the plurality of three-dimensional electrogram surfaces or data sets through time in the computing device to generate a vector map or visualization corresponding at least partially to the electrode spatial or areal positions, the vector map or visualization being configured to reveal the location of the source of the at least one cardiac rhythm disorder, and

(f) displaying to a user on the display the vector map or visualization.

78. The system of claim 77, wherein at least portions of the electrogram surfaces or data sets generated by the computing device are configured to correspond to estimated wave shapes or wavefront. (0)

79. The system of claim 77, wherein the electrogram surfaces or data sets are generated by the computing device using Green's function. (0)

80. The system of claim 77, wherein the electrogram surfaces or data sets are generated by the computing device using a two-dimensional bi-harmonic spline interpolation function. (0)

81. The system of claim 77, wherein the vector map or data sets generated by the computing device comprise arrows or colors representative of directions of electrical potential propagation. (0)

82. The system of claim 77, wherein the vector map or data sets generated by the computing device comprises arrows or colors having attributes representative of velocities of electrical potential propagation. (0)

83. The system of claim 77, wherein the vector map or data sets generated by the computing device are configured to reveal the at least one cardiac rhythm disorder as an active rotor at the location. (0)

84. The system of claim 77, wherein the vector map generated by the computing device is configured to reveal a location of a passive rotor in the patient's heart. (0)

85. The system of claim 77, wherein the vector map generated by the computing device is configured to reveal a location of a focal point in the patient's heart. (0)

86. The system of claim 77, wherein the vector map generated by the computing device is configured to reveal a location of a breakthrough point in the patient's heart. (0)

87. The system of claim 77, wherein the velocity vector map is generated by the computing device using at least one optical flow analysis technique. (1) (0)

89. The system of claim 77, wherein the plurality of electrogram signals are processed by the computing device to generate an averaged electrogram signal, and the averaged electrogram signal is subtracted from each of the individual electrogram signals to generate artifact- or far-field adjusted individual electrogram (1) (0)

92. The system of claim 77, wherein interpolated or estimated values are generated by the computing device for positions in between the measured or calculated grid values corresponding to one or more of the electrogram signals, the plurality of smoothed electrogram surfaces, and the velocity vector map. (0)

93. The system of claim 77, wherein a representative amplitude value is generated by the computing device for each individual electrogram signal, and the representative amplitude value generated for each electrogram signal is stored for later use in image backgrounds that show low signal amplitude areas, the low signal amplitude areas being indicative of one or more of valve artifacts, poor electrode contact, and fibrotic areas of the heart. (0)

94. The system of claim 77, wherein the electrode positions in the 2D representation are modified by the computing device based upon navigational or positional data corresponding to measured or sensed actual electrode positions. (1) (0)

96. The system of claim 77, further, comprising an ablation system comprising an ablation catheter, the ablation catheter being configured for ablating the patient's heart at the location and source of the cardiac rhythm disorder indicated by the vector map. (0)

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Application US20190142271

Systems, Devices, Components and Methods for Detecting the Locations of Sources of Cardiac Rhythm Disorders in a Patient's Heart

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