Application US20180305760

Pathogen biomarkers and uses therefor
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US20180305760

1. A method for determining an indicator used in assessing a likelihood of a subject having a presence, absence or degree of VaSIRS, the method comprising, consisting or consisting essentially of: (1) determining a biomarker value that is measured or derived for at least one (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more) corresponding VaSIRS biomarker in a sample taken from the subject and that is at least partially indicative of a level of the VaSIRS biomarker in the sample; and (2) determining the indicator using the biomarker value, wherein the subject has at least one clinical sign of SIRS and the at least one VaSIRS biomarker is not a biomarker of at least one other SIRS condition selected from the group consisting of: bacterium associated SIRS, autoimmune disease associated SIRS, cancer associated SIRS and trauma associated SIRS. (1) (0)

2. A method according to claim 1, wherein the at least one VaSIRS biomarker is an expression product of a gene selected from the group consisting of: ZBP1, TMEM62, CD38, ISG15, IFI44, RSAD2, HERC5, MX1, HERC6, OAS2, XAF1, IFI6, PARP12, EIF2AK2, DHX58, UBE2L6, DDX60, USP18, RTP4, PHF11, IFIH1, ZBP1, STAT1, LAP3, TAP1, C19orf66, CUL1, POLB, ZC3HAV1, IL16, ITPKB, CAMK2G, CTDSP2, DPEP2, LTB, CBX7, FNBP1, FOXO1, MAST3, LDLRAP1, TMEM204, FAIM3, RGS14, IKBKB, ZXDC, PHF20, DGKA, XPC, PPARD, C2orf58, NLRP1, IL27RA, ABLIM1, JAK1, METTL3, SAFB2, PPM1F, TYK2, BANP, CRTC3, ATM, PAFAH1B1, PIK3IP1, WDR37, TGFBR2, ZNF274, STAT5B, MAML1, SATB1, DOCK9, CHMP7, BRD1, BTG1, ATF7IP2, DIDO1, LEF1, TNRC6B, SERTAD2, CEP68, BCL2, VPS8, CHD3, PUM2, TGOLN2, NDE1, CCR7, PSTPIP1, TIAM1, PECAM1, PDE3B, MYC, FOXJ2, PRMT2, CSNK1D, RPL10A, SERINC5, ARHGEF2, HGSNAT, TRAK1, PHF2, PBX3, SESN1, DPF2, IL4R, NOSIP, MPPE1, NR3C1, ABAT, GCC2, ZFC3H1, SETD2, ITSN2, R3HDM2, ARHGAP15, PCF11, MAPRE2, ST3GAL1, NACA, WDR47, SSBP2, CLK4, EIF3H, FRY, ZNF238, PTGER4, PCNX, NECAP2, CASC3, MSL1, VEZF1, KIAA0232, RASSF2, RPL22, ACAA1, MAP4K4, BEX4, NCBP2, LRMP, CAMK1D, UTP14A, STX6, RPS6KA3, PRKAA1, GOLGA7, ZNF143, SNRK, SYPL1, CYLD, PRUNE, CRLF3, CD93, GPS2, FBXO11, UBE2D2, USP10, CCNG2, SOS2, ARRB1, CEP170, SMAD4, CIAPIN1, KLF7, PHF20L1, ALDH3A2, PDCD6IP, WASF2, TGFBI, GPBP1L1, PCBP2, DCP2, LYST, ERBB2IP, ANKRD49, NDFIP1, ATAD2B, ZNF292, CCNT2, MARCH7, ACAP2, MED13, IL6ST, PHF3, SP3, SEC62, ZFYVE16, NEK7, POLD4, GNA12, TRIB2, YTHDF3, PPP2R5A, PPP1R2, ZDHHC17, STK38L, ST13, FAM134A, PFDN5, MARCH8, POLR1D, OASL, N4BP1, NOD2, RNF19B, PRKAG2, IGSF6, MEF2A, LPIN2, PPP1R11, USP15, BACH1, SSFA2, MKLN1, FYB, NSUN3, MAX, STAM2, HHEX, CLEC4A, ZFAND5, ABI1, MORC3, RC3H2, MAP1LC3B, TM2D3, CHST11, NAB1, KLF3, YPEL5, MXI1, CD97, CYTH4, HCK, ARHGAP26, RARA, XPO6, TNFRSF1A, SLCO3A1, ICAM3, PTPN6, PRKCD, RAB11FIP1, CSF2RB, LCP2, TYROBP, PHC2, RHOG, PSAP, LYN, TMEM127, LILRA2, AOAH, FGR, PLEKHO2, ARAP1, RBM23, PTPRE, KLF6, LIMK2, LILRB3, TLR2, GPR97, GMIP, SIRPA, LRP10, LPAR2, TREM1, IL13RA1, ITGAX, ARHGAP25, SIRPB1, ZDHHC18, TLE3, ITGB2, SNX27, PGS1, ATP6V1B2, RAB31, MAP3K11, PACSIN2, KIAA0513, EMR2, RERE, NUMB, RALB, ETS2, STAT5A, LST1, RIN3, TNK2, IQSEC1, PISD, SORL1, FES, KIAA0247, IL6R, LAPTM5, VAMP3, FAM65B, MAP3K5, TRIM8, ZYX, MAPK14, PLEKHO1, NCOA1, RNASET2, APBB1IP, RXRA, PTAFR, CNPY3, TNFSF13, RPS6KA1, OSBPL2, MTMR3, TMBIM1, TFEB, TFE3, RAF1, STX3, LAT2, GRB2, NDEL1, SEMA4D, FCGRT, DOK3, HIP1, UBN1, PLXNC1, NRBF2, INPP5D, SH2D3C, MMP25, IL1ORB, FLOT2, PIAS1, PITPNA, APLP2, CTBP2, GPSM3, RNF130, DGCR2, ZMIZ1, CAP1, GSK3B, RGS19, RAB7A, CREBBP, RBMS1, IL1RAP, RTN3, PPP4R1, TRIOBP, GABARAP, MCTP2, NFKB1, CST3, ABHD2, SH2B3, STX10, TSC22D3, TLE4, HAL, ARRB2, MAP3K3, NPL, CCND3, SERINC3, GNAQ, USP4, PSEN1, KBTBD2, LYL1, AIF1, MBP, ACVR1B, RAB4B, PTEN, ASAP1, MANSC1, RYBP, CSAD, UBXN2B, TNIP1, WBP2, OGFRL1, SNN, HPCAL1, CD37, RNF146, RAB14, TOPORS, NFYA, FOXO3, CREB1, MAPK1, SOAT1, UBQLN2, OSBPL11, KLHL2, VAV3, BRD4, MARK3, BAZ2B, ZNF148, CASP8, CHMP1B, HPS1, RNF141, MOSPD2, PINK1, CDIPT, NCOA4, PPP3R1, MKRN1, GYPC, BMP2K and FBXO9. (1) (0)

25. An apparatus for determining an indicator used in assessing a likelihood of a subject having a presence, absence or degree of VaSIRS, the apparatus comprises at least one electronic processing device that: (0) (3)

26. A composition for determining an indicator used in assessing a likelihood of a subject having a presence, absence or degree of VaSIRS, the composition comprising, consisting or consisting essentially of at least one pair of cDNAs and at least one oligonucleotide primer or probe that hybridizes to an individual one of the cDNAs, wherein the at least one pair of cDNAs is selected from pairs of cDNA including a first pair and a second pair of cDNAs, wherein the first pair comprises a Group B VaSIRS biomarker cDNA and a Group C VaSIRS biomarker cDNA and wherein the second pair comprises a Group D VaSIRS biomarker cDNA and a Group E VaSIRS biomarker cDNA. (1) (0)

35. A kit for determining an indicator indicative of the likelihood of the presence, absence or degree of VaSIRS, the kit comprising, consisting or consisting essentially of at least one pair of reagents selected from reagent pairs including a first pair of reagents and a second pair of reagents, wherein the first pair of reagents comprises (i) a reagent that allows quantification of a Group B VaSIRS biomarker; and (ii) a reagent that allows quantification of a Group C VaSIRS biomarker, wherein the second pair of reagents comprises: (iii) a reagent that allows quantification of a Group D VaSIRS biomarker; and (iv) a reagent that allows quantification of a Group E VaSIRS biomarker. (0)

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Application US20180305760

Pathogen biomarkers and uses therefor

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