Patent US11065227

Use of cannabinoids in the treatment of multiple myeloma
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US11065227

1. A method for treating multiple myeloma comprising administering to a subject in need thereof a therapeutically effective amount of a cannabis extract and a proteasome inhibitor, (13) (2)

wherein the cannabis extract comprises the cannabinoids tetrahydrocannabinol (THC) and cannabidiol (CBD), wherein THC and CBD are present at greater than 98% (w/w) in the extract, and

wherein the proteasome inhibitor is bortezomib, carfilzomib or ixazomib.

2. The method of claim 1, further comprising administering one or more additional medications. (0)

3. The method of claim 1, wherein the proteasome inhibitor is bortezomib or carfilzomib. (1) (0)

4. The method of claim 1, wherein the proteasome inhibitor is carfilzomib. (1) (0)

5. The method of claim 1, wherein the proteasome inhibitor is administered at a dose that is reduced relative to a dose of proteasome inhibitor administered prior to treatment with the THC and CBD. (0)

6. The method of claim 1, wherein the proteasome inhibitor is administered at a dose that is reduced relative to a therapeutically effective dose of the proteasome inhibitor for the subject without treatment with the THC and CBD. (0)

7. The method of claim 1, wherein the proteasome inhibitor is administered at a dose of less than 27 mg/m²IV. (0)

8. The method of claim 1, wherein the proteasome inhibitor is administered at a dose of less than 20 mg/m²IV. (0)

9. The method of claim 1, wherein the THC, CBD, or both are administered at a dose of from 0.1 to 1000 mg/kg/day. (0)

10. The method of claim 1, wherein the THC and CBD are present in a ratio of from 99:1 to 1:99 (THC:CBD). (0)

11. The method of claim 1, wherein the THC and CBD are present in a ratio of from 10:1 to 1:10 (THC:CBD). (0)

12. The method of claim 1, wherein the THC and CBD are present in a ratio of from 5:1 to 1:5 (THC:CBD). (0)

13. The method of claim 1, wherein the THC and CBD are present in a ratio of approximately 1:1 (THC:CBD). (0)

15. The method of claim 1, wherein treating reduces chemotaxis of multiple myeloma cells to cells expressing SDF-1, eCypA, or both. (0)

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Patent US11065227

Use of cannabinoids in the treatment of multiple myeloma

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