Patent US10695361

or a pharmaceutically acceptable salt thereof;

R7 is selected from the group consisting of a) —C(═O)R11, —C(═O)OR11, —C(═O)NR11R12, —C(═O)SR11, —S(O)R11, —S(O)2R11, —S(O)(OR11), —S(O)2(OR11), and —SO2NR11R12, wherein each R11 and R12 is independently H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, (C4-C8)carbocyclylalkyl, optionally substituted aryl, optionally substituted heteroaryl, —C(═O)(C1-C8)alkyl, —S(O)n(C1-C8)alkyl or aryl(C1-C8)alkyl; or R11 and R12 taken together with a nitrogen to which they are both attached form a 3 to 7 membered heterocyclic ring wherein any one carbon atom of said heterocyclic ring is optionally replaced with —O—, —S— or —NRa—; each Ra is independently H, (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl, aryl(C1-C8)alkyl, (C4-C8)carbocyclylalkyl, —C(═O)R, —C(═O)OR, —C(═O)NR2, —C(═O)SR, —S(O)R, —S(O)2R, —S(O)(OR), —S(O)2(OR), or —SO2NR2; wherein each R is independently H, (C1-C8) alkyl, (C1-C8) substituted alkyl, (C2-C8)alkenyl, (C2-C8) substituted alkenyl, (C2-C8) alkynyl, (C2-C8) substituted alkynyl, C6-C20 aryl, C6-C20 substituted aryl, C2-C20 heterocyclyl, C2-C20 substituted heterocyclyl, arylalkyl or substituted arylalkyl; and wherein each (C1-C8)alkyl, (C2-C8)alkenyl, (C2-C8)alkynyl or aryl(C1-C8)alkyl of each R11 and R12 is, independently, optionally substituted with one or more halo, hydroxy, CN, N3, N(Ra)2 or ORa; and wherein one or more of the non-terminal carbon atoms of each said (C1-C8)alkyl is optionally replaced with —O—, —S— or —NRa—,

wherein: Rc is selected from the group consisting of phenyl, 1-naphthyl, 2-naphthyl,

Rd is H or CH3; Re1 and Re2 are each independently H, C1-C6 alkyl or benzyl; and Rf is selected from the group consisting of H, C1-C8 alkyl, benzyl, C3-C6 cycloalkyl, and —CH2—C3-C6 cycloalkyl; and d) a group of the formula:

wherein Q is O, S, NR, +N(O)(R), N(OR), +N(O)(OR), or N—NR2; Z1 and Z2, when taken together, are -Q1(C(Ry)2)3Q1-; wherein each Q1 is independently O, S, or NR; and each Ry is independently H, F, Cl, Br, I, OH, R, —C(=Q2)R, —C(=Q2)OR, —C(=Q2)N(R)2, —N(R)2, —+N(R)3, —SR, —S(O)R, —S(O)2R, —S(O)(OR), —S(O)2(OR), —OC(=Q2)R, —OC(=Q2)OR, —OC(=Q2)(N(R)2), —SC(=Q2)OR, —SC(=Q2)(N(R)2), —N(R)C(=Q2)R, —N(R)C(=Q2)OR, —N(R)C(=Q2)N(R)2, —SO2NR2, —CN, —N3, —NO2, —OR, or Z3; or when taken together, two Ry on the same carbon atom form a carbocyclic ring of 3 to 7 carbon atoms; each Q2 is independently, O, S, NR, +N(O)(R), N(OR), +N(O)(OR), or N—NR2; or Z1 and Z2 are each, independently, a group of the Formula Ia:

wherein: each Q3 is independently a bond, O, CR2, NR, +N(O)(R), N(OR), +N(O)(OR), N—NR2, S—S, S(O), or S(O)2; M2 is 0, 1 or 2; each Rx is independently Ry or the formula:

wherein:  each M1a, M1c, and M1d is independently 0 or 1;  M12c is 0, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 or 12;  Z3 is Z4 or Z5;  Z4 is R, —C(Q2)Ry, —C(Q2)Z5, —SO2Ry, or —SO2Z5; and  Z5 is a carbocycle or a heterocycle wherein Z5 is independently substituted with 0 to 3 Ry groups.