Application US20210113831 Consumer Sleep Technology

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Stimscience Inc.

Application US20210113831

Published 2021-04-22

Systems, Methods, And Devices For Brain Stimulation And Monitoring

Provided are systems, methods, and devices for brain stimulation and monitoring. Brain stimulation may be provided to enhance slow wave and spindle synchrony. Such stimulation may provide increased memory consolidation. Furthermore, brain stimulation modalities may provide enhanced sleep and awakening. For example, transcranial direct current stimulation of the brain stimulation may enhance sleep quality. Moreover, one or more markers characterizing unconsciousness are may be identified based on changes in measured power densities or spectra. Further still, the above described modalities of brain stimulation may be implemented in an open-loop or closed loop manner. Brain state parameters may be generated for building models of the brain based on determined synchrony patterns between slow waves and spindles. The models may be used to determine a mediation procedure for adjusting the intensity of slow wave oscillations to enhance slow wave and spindle synchrony.

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3 Independent Claims

1. A method comprising: obtaining a plurality of measurements from a brain of a user via an interface, wherein the plurality of measurements includes indications of slow wave oscillations and sleep spindles; generating, via a processing device, a plurality of brain state parameters characterizing one or more features of at least one brain state of the brain of the user, wherein the plurality of brain state parameters includes an indication of a synchrony pattern between the measured slow wave oscillations and the measured sleep spindles including an assessment of a temporal directionality of interactions between the measured slow wave oscillations and sleep spindles and an amount of temporal deviation between slow wave oscillation peaks and sleep spindle peaks; and transmitting one or more control signals from a controller to the interface to apply one or more stimuli to cortical tissue of the brain, wherein the one or more stimuli is configured to enhance synchrony of slow wave oscillations and sleep spindles such that sleep spindle peaks occur closer to slow wave oscillation peaks.
8. A system comprising: an interface configured to obtain a plurality of measurements from a brain of a user, wherein the plurality of measurements includes indications of slow wave oscillations and sleep spindles; a processing device configured to generate a plurality of brain state parameters characterizing one or more features of at least one brain state of the brain of the user, wherein the brain state parameters include an indication of a synchrony pattern between the measured slow wave oscillations and the measured sleep spindles including an assessment of a temporal directionality of interactions between the measured slow wave oscillations and sleep spindles and an amount of temporal deviation between slow wave oscillation peaks and sleep spindle peaks; and a controller configured to transmit one or more control signals to apply one or more stimuli to cortical tissue of the brain, wherein the one or more stimuli is configured to enhance synchrony of slow wave oscillations and sleep spindles such that sleep spindle peaks occur closer to slow wave oscillation peaks.
15. A non-transitory computer readable medium storing one or more programs configured for execution by a computer, the one or more programs comprising instructions for: obtaining a plurality of measurements from a brain of a user via an interface, wherein the plurality of measurements includes indications of slow wave oscillations and sleep spindles; generating, via a processing device, a plurality of brain state parameters characterizing one or more features of at least one brain state of the brain of the user, wherein the plurality of brain state parameters includes an indication of a synchrony pattern between the measured slow wave oscillations and the measured sleep spindles including an assessment of a temporal directionality of interactions between the measured slow wave oscillations and sleep spindles and an amount of temporal deviation between slow wave oscillation peaks and sleep spindle peaks; and transmitting one or more control signals from a controller to the interface to apply one or more stimuli to cortical tissue of the brain, wherein the one or more stimuli is configured to enhance synchrony of slow wave oscillations and sleep spindles such that sleep spindle peaks occur closer to slow wave oscillation peaks.