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AI Biotech/Diagnostics: Other Innovation
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Application US20180305760
Published 2018-10-25
Pathogen Biomarkers And Uses Therefor
Disclosed are compositions, methods and apparatus for diagnosing and/or monitoring a virus-associated systemic inflammation by measurement of a host immune response. The invention can be used for diagnosis including early diagnosis, monitoring, making treatment decisions, or management of subjects suspected of having systemic inflammation associated with an infection. More particularly, the present disclosure relates to peripheral blood RNA and protein biomarkers that are useful for specifically distinguishing between the host systemic immune response to viruses as compared to the host immune response to other causes of systemic inflammation.
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- 1. A method for determining an indicator used in assessing a likelihood of a subject having a presence, absence or degree of VaSIRS, the method comprising, consisting or consisting essentially of: (1) determining a biomarker value that is measured or derived for at least one (e.g., 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, or more) corresponding VaSIRS biomarker in a sample taken from the subject and that is at least partially indicative of a level of the VaSIRS biomarker in the sample; and (2) determining the indicator using the biomarker value, wherein the subject has at least one clinical sign of SIRS and the at least one VaSIRS biomarker is not a biomarker of at least one other SIRS condition selected from the group consisting of: bacterium associated SIRS, autoimmune disease associated SIRS, cancer associated SIRS and trauma associated SIRS.
- 25. An apparatus for determining an indicator used in assessing a likelihood of a subject having a presence, absence or degree of VaSIRS, the apparatus comprises at least one electronic processing device that:
determines a pair of biomarker values, each biomarker value being a value measured or derived for at least one corresponding VaSIRS biomarker, as broadly described above and elsewhere herein, of a sample taken from the subject and being at least partially indicative of a concentration of the VaSIRS biomarker in the sample; determines a derived biomarker value using the pair of biomarker values, the derived biomarker value being indicative of a ratio of concentrations of the pair of VaSIRS biomarkers; and determines the indicator using the derived biomarker value.
- 26. A composition for determining an indicator used in assessing a likelihood of a subject having a presence, absence or degree of VaSIRS, the composition comprising, consisting or consisting essentially of at least one pair of cDNAs and at least one oligonucleotide primer or probe that hybridizes to an individual one of the cDNAs, wherein the at least one pair of cDNAs is selected from pairs of cDNA including a first pair and a second pair of cDNAs, wherein the first pair comprises a Group B VaSIRS biomarker cDNA and a Group C VaSIRS biomarker cDNA and wherein the second pair comprises a Group D VaSIRS biomarker cDNA and a Group E VaSIRS biomarker cDNA.
- 35. A kit for determining an indicator indicative of the likelihood of the presence, absence or degree of VaSIRS, the kit comprising, consisting or consisting essentially of at least one pair of reagents selected from reagent pairs including a first pair of reagents and a second pair of reagents, wherein the first pair of reagents comprises (i) a reagent that allows quantification of a Group B VaSIRS biomarker; and (ii) a reagent that allows quantification of a Group C VaSIRS biomarker, wherein the second pair of reagents comprises: (iii) a reagent that allows quantification of a Group D VaSIRS biomarker; and (iv) a reagent that allows quantification of a Group E VaSIRS biomarker.
