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AI Biotech/Diagnostics: General Diagnostics
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Application US20190101527
Published 2019-04-04
Systems And Methods For Discovery And Analysis Of Markers
A business method for use in classifying patient samples. The method includes steps of collecting case samples representing a clinical phenotypic state and control samples representing patients without said clinical phenotypic state. Preferably the system uses a mass spectrometry platform system to identify patterns of polypeptides in said case samples and in the control samples without regard to the specific identity of at least some of said polypeptides. Based on identified representative patterns of the state, the business method provides for the marketing of diagnostic products using representative patterns. The present invention relates to systems and methods for identifying new markers, diagnosing patients with a biological state of interest, and marketing/commercializing such diagnostics. The present invention relates to systems and methods of greater sensitivity, specificity, and/or cost effectiveness.
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- 1.-20. (canceled)
- 21. A method for generating one or more phenotype classifications of proteomic data derived from a plasma sample of a subject, comprising:
(a) obtaining said plasma sample from said subject, wherein said plasma sample comprises plasma microparticles; (b) isolating said plasma microparticles from said plasma sample thereby obtaining isolated plasma microparticles and enriching a subset proteins present in said plasma sample; (c) assaying said isolated plasma microparticles to generate proteomic data; and (d) processing said proteomic data of (c) using a trained classifier, wherein said trained classifier assigns one or more phenotype classifications to said proteomic data of said subject based on one or more features of said proteomic data, thereby generating said one or more phenotype classifications of said proteomic data derived from said plasma sample of said subject.
