Application US20190142271 AI Biotech/Diagnostics: Cardio

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Application US20190142271

Published 2019-05-16

Systems, Devices, Components And Methods For Detecting The Locations Of Sources Of Cardiac Rhythm Disorders In A Patient's Heart

Disclosed are various examples of embodiments of systems, devices, components and methods configured to detect a location of a source of at least one cardiac rhythm disorder in a patient's heart. In some embodiments, electrogram signals are acquired from inside a patient's heart, and subsequently normalized, adjusted and/or filtered, followed by generating a two-dimensional (2D) spatial map, grid or representation of the electrode positions, processing the amplitude-adjusted and filtered electrogram signals to generate a plurality of three-dimensional electrogram surfaces corresponding at least partially to the 2 D grid, one surface being generated for each or selected discrete times, and processing the plurality of three-dimensional electrogram surfaces through time to generate a velocity vector map corresponding at least partially to the 2 D grid. The resulting velocity vector map is configured to reveal the location of the source of the at least one cardiac rhythm disorder, which may be, by way of example, an active rotor in a patient's myocardium and atrium.

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77 Independent Claims

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77. A method of detecting a location of a source of at least one cardiac rhythm disorder in a patient's heart using at least one computing device and a display operably connected thereto, where the at least one computing device comprises at least one non-transitory computer readable medium configured to store instructions executable by at least one processor for determining the source and location of the cardiac rhythm disorder in the patient's heart, the method comprising: (a) receiving electrogram signals from an array of electrodes positioned in or on a patient; (b) normalizing and/or adjusting amplitudes of the electrogram signals in the data acquisition device; (c) assigning predetermined spatial or areal positions of electrodes to the electrodes and their corresponding electrogram signals in the computing device; (d) for each or selected discrete times over which the electrogram signals are being processed, processing the amplitude-adjusted electrogram signals in the computing device to generate a plurality of three-dimensional electrogram surfaces or data sets corresponding at least partially to the electrode positions, one surface or data set being generated for each such time; (e) processing the plurality of three-dimensional electrogram surfaces or data sets through time in the computing device to generate a vector map or visualization corresponding at least partially to the electrode spatial or areal positions, the vector map or visualization being configured to reveal the location of the source of the at least one cardiac rhythm disorder, and (f) displaying to a user on the display the vector map or visualization.