Home Patent Forecast® Sectors Log In   Contact  
How it works Patent Forecast® Sectors Insights
Menu

Pandemics/Epidemics (Free)


  1. Home
  2. News and Insights
  3. Companies
  4. Patents
  5. Applications
  6. Visualization
  7. Download
  8. Subscribe
  9. History
  1. Home
  2. Menu
  3. Patents

Search All Patents in Pandemics/Epidemics (Free)


Patent US9951002


Issued 2018-04-24

Ionizable Cationic Lipid For Rna Delivery

What is described is a compound having the formula

embedded image
wherein

    • R1 is branched alkyl of the structure (CH3(CH2)m)2CH—, wherein m is 2 or 3;
    • R2 is a linear alkyl of 1, 2, 3, 4, 5, 6, 7, 8, or 9 carbons, a branched alkyl of 3, 4, 5, 6, 7, 8, or 9 carbons, or an alkenyl or alkynyl of 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbons;
    • R3 is —(CH2)p—, wherein p is 2, 3, 4, 5 or 6;
    • R4 and R5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons;
    • L1 and L2 are the same or different, of the structure —(CH2)n—, wherein n is 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18;
    • L3 is a bond;
    • X1 is —CO—O— whereby -L2-CO—O—R2 is formed;
    • X2 is S or O; and
    • X3 is —CO—O— whereby -L1-CO—O—R1 is formed; and
      wherein m+n+p is 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, or 27;
      or a pharmaceutically acceptable salt thereof.



Much More than Average Length Specification


View the Patent Matrix® Diagram to Explore the Claim Relationships

USPTO Full Text Publication >

3 Independent Claims

  • 1. A compound of formula 2 R1 is branched alkyl of the structure (CH3(CH2)m)2CH—, wherein m is 2 or 3; R2 is a linear alkyl of 1, 2, 3, 4, 5, 6, 7, 8, or 9 carbons, a branched alkyl of 3, 4, 5, 6, 7, 8, or 9 carbons, or an alkenyl or alkynyl of 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbons; R3 is —(CH2)p—, wherein p is 2, 3, 4, 5 or 6; R4 and R5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; L1 and L2 are the same or different, of the structure —(CH2)n—, wherein n is 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18; L3 is a bond; X1 is —CO—O— whereby -L2-CO—O—R2 is formed; X2 is S or O; and X3 is —CO—O— whereby -L1-CO—O—R1 is formed; and

  • 11. A compound of formula 2 R1 is branched alkyl of the structure (CH3(CH2)m)2CH—, wherein m is 2 or 3; R2 is a linear alkyl of 1, 2, 3, 4, 5, 6, 7, 8, or 9 carbons, a branched alkyl of 3, 4, 5, 6, 7, 8, or 9 carbons, or an alkenyl or alkynyl of 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbons; R3 is —(CH2)p—, wherein p is 2, 3, 4, 5 or 6; R4 and R5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; L1 and L2 are the same or different, of the structure —(CH2)n—, wherein n is 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, or 18; L3 is of the structure —(CH2)q—, wherein q is 1, 2, 3, 4, 5 or 6; X1 is —CO—O—, whereby -L2-CO—O—R2 is formed; X2 is S or O; and X3 is —CO—O—, whereby -L1-CO—O—R1 is formed; and

  • 18. A compound of formula 2 R1 is branched alkyl of the structure (CH3(CH2)m)2CH—, wherein m is 1, 2, or 3; R2 is a linear alkyl of 1, 2, 3, 4, 5, 6, 7, 8, or 9 carbons, a branched alkyl of 3, 4, 5, 6, 7, 8, or 9 carbons, or an alkenyl or alkynyl of 2, 3, 4, 5, 6, 7, 8, 9, 10 or 11 carbons; R3 is —(CH2)p—, wherein p is 2, 3, 4, 5 or 6; R4 and R5 are the same or different, each a hydrogen, or a linear or branched alkyl of 1, 2, 3, 4, 5 or 6 carbons; L1 and L2 are the same or different, of the structure —(CH2)n—CH═CH—(CH2)r—, wherein n and r each is independently selected from 1 to 15, wherein n+r is 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, or 16; L3 is a bond; X1 is —CO—O— whereby -L2-CO—O—R2 is formed; X2 is S or O; and X3 is —CO—O— whereby -L1-CO—O—R1 is formed; and