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Patent US10842867
Issued 2020-11-24
Adjuvanted Vaccines With Non-virion Antigens Prepared From Influenza Viruses Grown In Cell Culture
An immunogenic composition comprising (i) a non-virion influenza virus antigen prepared from a virus grown in cell culture; and (ii) an adjuvant. Preferred adjuvants comprise oil-in-water emulsions.
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- 1. An immunogenic composition comprising:
(i) a purified surface antigen, prepared from a cell culture-grown human influenza virus; and (ii) an adjuvant comprising an oil-in-water emulsion, wherein the composition is free from chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5% polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and has sub-micron droplets.
- 8. A method for preparing an immunogenic composition comprising the steps of combining:
(i) a purified surface antigen, prepared from a cell culture-grown human influenza virus; and (ii) an adjuvant comprising an oil-in-water emulsion, wherein the composition is free from chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5% polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and has sub-micron droplets.
- 9. A kit comprising:
(i) a first kit component comprising a purified surface antigen, prepared from a cell culture-grown human influenza virus; and (ii) a second kit component comprising an adjuvant comprising an oil-in-water emulsion, wherein the first kit component is free from chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5% polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and has sub-micron droplets.
- 10. An immunogenic composition comprising:
(i) a purified surface antigen, prepared from a cell culture-grown human influenza virus; and (ii) an adjuvant comprising an oil-in-water emulsion and a tocopherol, wherein the composition is free from chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5% polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and has sub-micron droplets.
- 12. An immunogenic composition comprising:
(i) a purified surface antigen, prepared from a cell culture-grown virus; and (ii) an adjuvant comprising an oil-in-water emulsion, wherein the composition is a trivalent vaccine comprising influenza antigens from one H1N1 influenza A strain, one H3N2 influenza A strain and one influenza B strain, wherein the composition is free from chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5% polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and has sub-micron droplets.
