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Patent US10729764
Issued 2020-08-04
Iscom Preparation And Use Thereof
The invention relates to a composition comprising a mixture of at least two iscom complexes each complex comprising essentially one saponin fraction from Quillaja Saponaria Molina. The complexes may be iscom complexes or iscom matrix complexes. The invention also pertains to the use of such a mixture for the preparation of an immunomodulating pharmaceutical, and adjuvant, formulations for immunization, e.g. for production of monoclonal antibodies, and a vaccine. Kits of parts comprising at least two parts, wherein each part comprises one iscom complex or one iscom matrix complex according to the invention are also embraced.
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- 1. A composition comprising at least two iscom particles, wherein:
the first iscom particle comprises fraction A of Quillaja saponaria Molina and not fraction C of Quillaja saponaria Molina; and the second iscom particle comprises fraction C of Quillaja saponaria Molina and not fraction A of Quillaja saponaria Molina.
- 13. A composition comprising at least two iscom particles, wherein: the first iscom particle consists essentially of fraction A of Quillaja saponaria Molina; the second iscom particle consists essentially of fraction C of Quillaja saponaria Molina; and the composition has a lower toxicity than a corresponding composition in which corresponding amounts of fraction A of Quillaja saponaria Molina and fraction C of Quillaja saponaria Molina are integrated together in iscom particles of the corresponding composition instead of separately in the first and second iscom particles.
