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Patent US10562835
Issued 2020-02-18
Method For Producing Thorium-226
Disclosed herein are embodiments of a method for producing thorium-226. The method comprises separating thorium-226 from uranium-230 to produce a solution of thorium-226 in a solvent, such as a chelating buffer, suitable for direct labeling by a chelate. The thorium-226 may be separated from the uranium-230 using extraction chromatography. The extraction may be repeated multiple times as additional thorium-226 is produced by uranium-230 decay.
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- 1. A method, comprising:
forming a first solution comprising uranium-230 and thorium-226; contacting a first resin with the first solution such that the uranium-230 and the thorium-226 bind to the first resin, wherein the first resin is a diglycolamide resin, a monoamide resin, a malonamide resin, or a multi-podant DGA ligand, eluting the thorium-226 from the first resin with a carboxylic acid-based chelating buffer to form a second solution comprising the thorium-226 and the carboxylic acid-based chelating buffer.
- 10. A method, comprising:
forming a first solution comprising uranium-230 and thorium-226; contacting a first resin selected from a phosphonic acid resin, a phosphine oxide resin, or a phosphine sulfide resin with the first solution such that the uranium-230 and the thorium-226 bind to the first resin; eluting the thorium-226 from the first resin with a mineral acid to form a second solution, the mineral acid having an acid concentration of from 0.5 M to 4 M; contacting a cation exchange resin with the second solution; and eluting the thorium-226 from the cation exchange resin with the chelating buffer to form a third solution.
- 16. A method, comprising:
forming a first solution comprising uranium-230 and thorium-226 in 6M hydrochloric acid; contacting a diglycolamide resin with the first solution to bind the uranium-230 and thorium-226 to the resin; eluting the uranium-230 from the resin with nitric acid having a nitric acid concentration of from 0.01 M to 0.25 M, to form a second solution comprising uranium-230; eluting the thorium-226 from the resin with a chelating buffer to form a third solution comprising thorium-226, the chelating buffer comprising a carboxylic acid and having a pH of from 2 to 6.
