Application US20200060603 AI Biotech/Diagnostics: Other Innovation

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Application US20200060603

Published 2020-02-27

Cognitive Platform Configured As A Biomarker Or Other Type Of Marker

Example systems, methods, and apparatus are provided for using data collected from the responses of an individual with the computerized tasks of a cognitive platform to derive performance metrics as an indicator of cognitive abilities, and applying predictive models to generate an indication of neurodegenerative condition. The example systems, methods, and apparatus also can be configured to adapt the computerized tasks to enhance the individual's cognitive abilities, and for using data collected from the responses of an individual with the adapted computerized tasks to derive performance metrics and applying predictive models to generate the indication of neurodegenerative condition.

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3 Independent Claims

1. An apparatus for generating an assessment of one or more cognitive skills in an individual as an indication of a neurodegenerative condition of the individual, said apparatus comprising: a user interface; a memory to store processor-executable instructions; and a processing unit communicatively coupled to the user interface and the memory, wherein upon execution of the processor-executable instructions by the processing unit, the processing unit is configured to: render a first instance of a primary task at the user interface, requiring a first primary response from the individual to the first instance of the primary task; render a first instance of a secondary task at the user interface, requiring a first secondary response from the individual to the first instance of the secondary task; render at the user interface a second instance of the primary task with an interference, requiring a second primary response from the individual to the second instance of the primary task in the presence of the interference; wherein the interference is configured to divert the individual's attention from the second instance of the primary task and is configured as a second instance of the secondary task that is rendered as an interruptor or a distraction; using the user interface, instruct the individual not to respond to the interference that is configured as a distraction and to respond to the interference that is configured as an interruptor; receive data indicative of the first primary response, the first secondary response, the second primary response, and the response to the interference; analyze the differences in the individual's performance from performing the primary task without interference and with interference at least in part by determining differences between the data indicative of the first primary response and the second primary response, and also analyzing one or both of the first secondary response or the response to the interference, to determine at least one indicator of the cognitive ability of the individual; and generate a scoring output indicative of a likelihood of onset of a neurodegenerative condition of the individual and/or a stage of progression of the neurodegenerative condition based at least in part on applying the first predictive model to the at least one indicator.
22. A computer-implemented method for enhancing one or more cognitive skills in an individual to provide an indication of a neurodegenerative condition of the individual, said method being implemented using a computing device comprising a processing unit and an input device, said method comprising: using the processing unit, executing a first trial at a first time interval, the first trial comprising: rendering a first instance of a primary task, requiring a first primary response from the individual to the first instance of the primary task using the input device; rendering a second instance of the primary task with a first interference, requiring a second primary response from the individual, using the input device, to the second instance of the primary task in the presence of the first interference; wherein the first interference is configured to divert the individual's attention from the second instance of the primary task and is rendered as an interruptor or a distraction; and wherein the individual is instructed not to respond to the first interference that is configured as a distraction and to respond to the first interference that is configured as an interruptor; using the processing unit, executing a second trial at a second time interval that is subsequent to the first time interval, the second trial comprising: rendering a third instance of the primary task, requiring a third primary response from the individual to the third instance of the primary task using the input device; render a fourth instance of the primary task with a second interference, requiring a fourth primary response from the individual using the input device, to the fourth instance of the primary task in the presence of the second interference; wherein the second interference is configured to divert the individual's attention from the fourth instance of the primary task and is rendered as the interruptor or the distraction; and wherein the individual is instructed not to respond to the second interference that is configured as the distraction and to respond to the second interference that is configured as the interruptor; receive data indicative of the first primary response, the second primary response, the third primary response, and the fourth primary response; using the processing unit, analyze the differences in the individual's performance from performing the primary task without interference and with interference at least in part by determining differences between the data indicative of the first primary response, the second primary response, the third primary response, and the fourth primary response, to determine at least a first indicator of the cognitive ability of the individual; and using the processing unit, generate a scoring output indicative of a likelihood of onset of a neurodegenerative condition of the individual and/or a stage of progression of the neurodegenerative condition based at least in part on applying the first predictive model to the at least the first indicator.
45. An apparatus for enhancing one or more cognitive skills in an individual to provide an indication of a neurodegenerative condition of the individual, said apparatus comprising: a user interface; a memory to store processor-executable instructions; and a processing unit communicatively coupled to the user interface and the memory, wherein upon execution of the processor-executable instructions by the processing unit, the processing unit is configured to: render a first instance of a primary task at the user interface, requiring a first primary response from the individual to the first instance of the primary task; render a first instance of a secondary task at the user interface, requiring a first secondary response from the individual to the first instance of the secondary task; using the user interface, instruct the individual not to respond to an interference with the primary task that is configured as a distraction and to respond to an interference with the primary task that is configured as an interruptor; render at the user interface a second instance of the primary task with a first interference, requiring a second primary response from the individual to the second instance of the primary task in the presence of the first interference; wherein the first interference is configured to divert the individual's attention from the second instance of the primary task and is configured as a second instance of the secondary task that is rendered as an interruptor or a distraction; receive data indicative of the first primary response, the first secondary response, the second primary response, and the response to the interference; adjust a difficulty of one or both of the primary task or the interference such that the apparatus renders one or both of a third instance of the primary task or a second interference at a second difficulty level; render at the user interface a third instance of the primary task with the second interference, requiring a third primary response from the individual to the third instance of the primary task in the presence of the second interference; receive data indicative of the third primary response and the response to the second interference; analyze the differences in the individual's performance from performing the primary task without interference and with interference at least in part by determining differences between the data indicative of two or more of the first primary response, the second primary response, and the third primary response, and also analyzing at least one of the first secondary response, the response to the first interference, or the response to the second interference, to determine at least one indicator of the cognitive ability of the individual; and generate a scoring output indicative of a likelihood of onset of a neurodegenerative condition of the individual and/or a stage of progression of the neurodegenerative condition, based at least in part on applying a first predictive model to the at least one indicator.