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AI Biotech/Diagnostics: Cardio


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Patent US10169541


Issued 2019-01-01

Method And Systems For Characterizing Skin Related Conditions

Embodiments of a method and system for characterizing a skin-related condition in relation to a user can include one or more of: a handling network operable to collect containers comprising material from a set of users, the handling network comprising a sequencing system operable to determine microorganism sequences from sequencing the material; a microbiome characterization system operable to: determine at least one of microbiome composition data and microbiome functional diversity data based on the microorganism sequences, collect supplementary data associated with the skin-related condition for the set of users, and transform the supplementary data and the at least one of the microbiome composition data and the microbiome functional diversity data into a characterization model; and a therapy system operable to promote a treatment to the user for the skin-related condition based on characterizing the user with the characterization model in relation to the skin-related condition.



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2 Independent Claims

  • 1. A system for evaluating a skin-related condition in relation to a user, the system comprising: a handling network operable to collect containers comprising material from a set of users, the handling network comprising: a library preparation system operable to fragment and perform multiplex amplification on the material using a primer compatible with a genetic target associated with the skin-related condition; a sequencing system operable to determine microorganism sequences from sequencing the material; a microbiome characterization system operable to: determine microbiome composition data and microbiome functional diversity data based on an alignment between the microorganism sequences and reference sequences associated with the skin-related condition, collect supplementary data associated with the skin-related condition for the set of users, and transform the supplementary data and features extracted from the microbiome composition data and the microbiome functional diversity data into a characterization model for the skin-related condition; and a treatment system operable to provide a treatment to the user for the skin-related condition based on characterizing the user with the characterization model in relation to the skin-related condition.

  • 10. A method for characterizing a skin-related condition in relation to a first user, the method comprising: generating a microbiome composition dataset and a microbiome functional diversity dataset based on microorganism sequences derived from biological samples from a set of users, wherein generating the microbiome composition dataset and the microbiome functional diversity dataset comprises: identifying primers for nucleic acid sequences associated with the skin-related condition, fragmenting nucleic acid material, amplifying the fragmented nucleic acid material using the identified primers, and determining an alignment of the microorganism sequences to reference sequences associated with the skin-related condition; receiving a supplementary dataset informative of the skin-related condition for the set of users; obtaining a set of skin-related feature-selection rules correlating the skin-related condition to a subset of microbiome composition features and a subset of microbiome functional diversity features; generating a feature set based on evaluating the microbiome composition dataset and the microbiome functional diversity dataset against the set of skin-related feature-selection rules; applying the feature set with the supplementary dataset to generate a characterization model for the skin-related condition; generating a first characterization of the first user in relation to the skin-related condition using the characterization model; and providing a therapy to the first user for the skin-related condition based on the first characterization.