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Patent US10842867
Inventor

Adjuvanted Vaccines With Non-virion Antigens Prepared From Influenza Viruses Grown In Cell Culture

An immunogenic composition comprising (i) a non-virion influenza virus antigen prepared from a virus grown in cell culture; and (ii) an adjuvant. Preferred adjuvants comprise oil-in-water emulsions.

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1 Independent Claims

  • Claim 1. An immunogenic composition comprising: (i) a purified surface antigen, prepared from a cell culture-grown human influenza virusand (ii) an adjuvant comprising anoil-in-water emulsion, wherein the composition is free from chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5% polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and hassub-micron droplets.
  • Claim 8. A method for preparing an immunogenic composition comprising the steps of combining: (i) a purified surface antigen, prepared from a cell culture-grown human influenza virusand (ii) an adjuvant comprising an oil-in-water emulsion, whereinthe composition is free from chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5% polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and has sub-micron droplets.
  • Claim 9. A kit comprising: (i) a first kit component comprising a purified surface antigen, prepared from a cell culture-grown human influenza virusand (ii) a second kit component comprising an adjuvant comprising an oil-in-water emulsion, whereinthe first kit component is free from chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5% polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and has sub-micron droplets.
  • Claim 10. An immunogenic composition comprising: (i) a purified surface antigen, prepared from a cell culture-grown human influenza virusand (ii) an adjuvant comprising an oil-in-water emulsion and a tocopherol, wherein the composition is freefrom chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5% polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and has sub-micron droplets.
  • Claim 12. An immunogenic composition comprising: (i) a purified surface antigen, prepared from a cell culture-grown virusand (ii) an adjuvant comprising an oil-in-water emulsion, wherein the composition is a trivalent vaccine comprising influenzaantigens from one H1N1 influenza A strain, one H3N2 influenza A strain and one influenza B strain, wherein the composition is free from chicken DNA, ovalbumin and ovomucoid, and wherein the emulsion includes about 4.3% squalene by weight, about 0.5%polysorbate 80 by weight and about 0.48% sorbitan trioleate by weight and has sub-micron droplets.


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