Pharmaceutical Compositions Comprising A Statin And A Cannabinoid And Uses Thereof
The invention relates to pharmaceutical compositions comprising a statin and a cannabinoid, and their use for the treatment of hypercholesterolemia and atherosclerosis. It has been found that compositions combining a statin and a cannabinoid are improved over existing statin formulations. The compositions of the invention for example allow for a lower effective dose of statin and a reduction of the adverse effects seen with statins taken alone. Dosing ranges and formulations suitable for oral, buccal, and sublingual administration are disclosed. Various specific cannabinoids such as cannabidiol and synthetic cannabidiols selected for their anti-inflammatory, antioxidant, and anti-atherosclerotic effect are shown to be particularly advantageous.
Claim CLM-00001. 1. A pharmaceutical composition in unit dosage form for once daily dosing, useful in treating a patient with a lipid disorder, which consists essentially of a statin-cannabidiol combination of:
(a) a reduced daily dosage amount of a statin; and (b) less than or equal to 500 mg of a cannabidiol; together with a pharmaceutically acceptable carrier, diluent, or excipient; wherein the reduced daily dosage amount of the statin is less than the lowest standard daily dosage amount for the statin when taken alone; and wherein the pharmaceutical composition is formulated for oral or mucosal administration and the statin-cannabidiol combination confers a synergistic effect compared to the statin and the cannabidiol administered alone in the same amounts, said synergistic effect responsible for the reduced daily dosage amount of the statin without loss of therapeutic effect, and wherein the statin is atorvastatin.
Claim CLM-00008. 8. A pharmaceutical composition for once daily dosing, useful in treating a patient with a lipid disorder, which consists essentially of a statin-cannabidiol combination of therapeutically effective amounts of:
(a) a reduced daily dosage amount of a statin; and (b) a cannabidiol; wherein the reduced daily dosage amount of the statin is less than the lowest standard daily dosage amount for the statin when taken alone; and wherein the pharmaceutical composition is formulated for oral or mucosal administration and the statin-cannabidiol combination confers a synergistic effect compared to the statin and the cannabidiol administered alone in the same amounts, said synergistic effect responsible for the reduced daily dosage amount of the statin without loss of therapeutic effect, and wherein the statin is atorvastatin.
Claim CLM-00013. 13. A method of treating a medical condition in a human in need of such treatment, the method comprising administering in combination to the human a synergistically and therapeutically effective amount of atorvastatin and a cannabidiol, and wherein the medical condition is selected from the group consisting of a dysregulation of cholesterol metabolism, myositis, rhabdomyolysis, and statin-associated myopathy.
