Application US20200330423

ORAL CANNABINOID TABLET
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US20200330423

1-106. (canceled) (0)

107. An oral chewable tablet for delivery of cannabinoids to mucosal surfaces comprising a population of particles and one or more cannabinoids, the population of particles comprising a) directly compressible (DC) sugar alcohol particles and b) non-directly compressible (non-DC) sugar alcohol particles being particles consisting essentially of pure sugar alcohol, the non-DC particles providing the tablet with a plurality of discrete non-DC areas. (18) (0)

109. The oral chewable tablet according to claim 107, wherein at least 30% by weight of the non-DC sugar alcohol particles have a particle size above 500 μm. (0)

110. The oral chewable tablet according to claim 107, wherein the one or more cannabinoids are present in an amount of 0.1 to 400 mg. (0)

111. The oral chewable tablet according to claim 107, wherein the one or more cannabinoids comprise cannabidiol (CBD), cannabidiolic acid (CBDA), cannabidivarin (CBDV), salts and derivatives thereof. (0)

112. The oral tablet according to claim 107, wherein the one or more cannabinoids comprise tetrahydrocannabinol (THC), tetrahydrocannabinolic acid (THCA), tetrahydrocannabivarin (THCV), salts and derivatives thereof. (0)

113. The oral chewable tablet according to claim 107, wherein the non-DC sugar alcohol particles are selected from non-DC particles of erythritol, maltitol, xylitol, isomalt, lactitol, mannitol, and combinations thereof. (0)

114. The oral chewable tablet according to claim 107, wherein the tablet comprises said non-DC sugar alcohol particles in an amount of at least 10% by weight of the tablet. (0)

115. The oral chewable tablet according to claim 107, wherein said DC sugar alcohol particles comprises sugar alcohols selected from DC particles of sorbitol, erythritol, xylitol, lactitol, maltitol, mannitol, isomalt, and combinations thereof. (0)

116. The oral chewable tablet according to claim 107, wherein the tablet has a weight ratio between said non-DC sugar alcohol particles and said DC sugar alcohol particles, which is between 0.3 and 0.7. (0)

117. The oral chewable tablet according to claim 107, wherein saliva generation upon mastication of the tablet is induced compared to a tablet without non-DC sugar alcohol particles. (0)

118. The oral chewable tablet according to claim 107, wherein the tablet generates more than 1.5 mL saliva within 30 seconds from onset of mastication. (0)

119. The oral chewable tablet according to claim 107, wherein the tablet further comprises a self-emulsifying system that when hydrated with saliva upon oral administration forms an emulsion for delivery of the one or more cannabinoids to a mucosal surface. (2) (0)

122. The oral chewable tablet according to claim 107, wherein the one or more cannabinoids are present in a premixture. (2) (0)

125. The oral chewable tablet according to claim 107, wherein said population of particles is comprised in a first module of the tablet and a second population of particles is comprised in a second module of the tablet. (1) (0)

127. The oral chewable tablet according to claim 107, wherein the one or more cannabinoids comprise at least one phytocannabinoid that forms part of an extract. (0)

128. The oral chewable tablet according to claim 107, wherein the one or more cannabinoids comprise at least one isolated cannabinoid. (0)

129. The oral tablet according to claim 107, wherein the one or more cannabinoids comprise at least one endocannabinoid or endocannabinoid-like compound, such as palmitoylethanolamide (PEA). (0)

130. The oral tablet according to claim 107, wherein the one or more cannabinoids comprise at least one water-soluble cannabinoid. (0)

131. A method of alleviating or treating a medical condition comprising administering an oral tablet according to claim 107. (0)

108. (canceled) (0)

132. An oral chewable tablet comprising a population of particles and one or more cannabinoids, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles being particles consisting essentially of sugar alcohol, the tablet being designed to turn into liquid within 20 seconds of mastication. (0)

133. An oral chewable tablet comprising a population of particles and one or more cannabinoids, the population of particles comprising directly compressible (DC) and non-directly compressible (non-DC) sugar alcohol particles selected from non-DC particles of erythritol, maltitol, xylitol, isomalt, lactitol, mannitol, and combinations thereof, the tablet being designed to dissolve within 20 seconds of mastication. (0)

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Application US20200330423

ORAL CANNABINOID TABLET

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