Abstract: |
The invention relates to pharmaceutical compositions comprising a statin and a cannabinoid, and their use for the treatment of hypercholesterolemia and atherosclerosis. It has been found that compositions combining a statin and a cannabinoid are improved over existing statin formulations. The compositions of the invention for example allow for a lower effective dose of statin and a reduction of the adverse effects seen with statins taken alone. Dosing ranges and formulations suitable for oral, buccal, and sublingual administration are disclosed. Various specific cannabinoids such as cannabidiol and synthetic cannabidiols selected for their anti-inflammatory, antioxidant, and anti-atherosclerotic effect are shown to be particularly advantageous. |
Inventor: |
Smeeding, James (Dallas, TX, US); Sherwood, Mathew (Silverthorne, CO, US) |
Applicant: |
Indication BioScience LLC (Silverthorne, CO, US) |
Face Assignee: |
Indication BioScience LLC (Silverthorne, CO, US) |
Filed: |
2017-10-01 |
Issued: |
2020-11-17 |
Claims: |
15 |
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US10835501
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1. A pharmaceutical composition in unit dosage form for once daily dosing, useful in treating a patient with a lipid disorder, which consists essentially of a statin-cannabidiol combination of:
(6)
(3)
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8. A pharmaceutical composition for once daily dosing, useful in treating a patient with a lipid disorder, which consists essentially of a statin-cannabidiol combination of therapeutically effective amounts of:
(4)
(3)
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13. A method of treating a medical condition in a human in need of such treatment, the method comprising administering in combination to the human a synergistically and therapeutically effective amount of atorvastatin and a cannabidiol, and wherein the medical condition is selected from the group consisting of a dysregulation of cholesterol metabolism, myositis, rhabdomyolysis, and statin-associated myopathy.
(2)
(0)
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