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Cannabis: Compositions

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Patent US10835501


Issued 2020-11-17

Pharmaceutical Compositions Comprising A Statin And A Cannabinoid And Uses Thereof

The invention relates to pharmaceutical compositions comprising a statin and a cannabinoid, and their use for the treatment of hypercholesterolemia and atherosclerosis. It has been found that compositions combining a statin and a cannabinoid are improved over existing statin formulations. The compositions of the invention for example allow for a lower effective dose of statin and a reduction of the adverse effects seen with statins taken alone. Dosing ranges and formulations suitable for oral, buccal, and sublingual administration are disclosed. Various specific cannabinoids such as cannabidiol and synthetic cannabidiols selected for their anti-inflammatory, antioxidant, and anti-atherosclerotic effect are shown to be particularly advantageous.


Classification


Slightly More than Average Length Specification


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USPTO Full Text Publication >

3 Independent Claims

  • Independent Claim 1. A pharmaceutical composition in unit dosage form for once daily dosing, useful in treating a patient with a lipid disorder, which consists essentially of astatin-cannabidiol combination of: (a) a reduced daily dosage amount of a statinand (b) less than or equal to 500 mg of a cannabidioltogether with a pharmaceutically acceptable carrier, diluent, or excipientwherein the reduced daily dosageamount of the statin is less than the lowest standard daily dosage amount for the statin when taken aloneand wherein the pharmaceutical composition is formulated for oral or mucosal administration and the statin-cannabidiol combination confers asynergistic effect compared to the statin and the cannabidiol administered alone in the same amounts, said synergistic effect responsible for the reduced daily dosage amount of the statin without loss of therapeutic effect, and wherein the statin isatorvastatin.

  • Independent Claim 8. A pharmaceutical composition for once daily dosing, useful in treating a patient with a lipid disorder, which consists essentially of a statin-cannabidiol combination of therapeutically effective amounts of: (a) a reduced daily dosage amountof a statinand (b) a cannabidiolwherein the reduced daily dosage amount of the statin is less than the lowest standard daily dosage amount for the statin when taken aloneand wherein the pharmaceutical composition is formulated for oral ormucosal administration and the statin-cannabidiol combination confers a synergistic effect compared to the statin and the cannabidiol administered alone in the same amounts, said synergistic effect responsible for the reduced daily dosage amount of thestatin without loss of therapeutic effect, and wherein the statin is atorvastatin.

  • Independent Claim 13. A method of treating a medical condition in a human in need of such treatment, the method comprising administering in combination to the human a synergistically and therapeutically effective amount of atorvastatin and a cannabidiol, andwherein the medical condition is selected from the group consisting of a dysregulation of cholesterol metabolism, myositis, rhabdomyolysis, and statin-associated myopathy.