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Patent US10282520
Issued 2019-05-07
Method And System For Microbiome-derived Diagnostics And Therapeutics For Neurological Health Issues
A method for at least one of characterizing, diagnosing and treating a neurological health issue in at least a subject, the method comprising: receiving an aggregate set of biological samples from a population of subjects; generating at least one of a microbiome composition dataset and a microbiome functional diversity dataset for the population of subjects; generating a characterization of the neurological health issue based upon features extracted from at least one of the microbiome composition dataset and the microbiome functional diversity dataset; based upon the characterization, generating a therapy model configured to correct the neurological health issue; and at an output device associated with the subject, promoting a therapy to the subject based upon the characterization and the therapy model.
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- 1. A method for at least one of characterizing, diagnosing, and treating an anxiety condition of a subject, the method comprising:
receiving an aggregate set of samples from a population of subjects comprising at least one subject associated with the anxiety condition; for each sample of the aggregate set of samples:
determining a microorganism nucleic acid sequence, comprising:
fragmenting nucleic acid material of the sample,
amplifying the fragmented nucleic acid material with a primer, and
determining an alignment of the microorganism nucleic acid sequence to a reference nucleic acid sequence;
generating a microbiome feature dataset for the population of subjects based upon the alignments; generating a characterization of the anxiety condition based upon the microbiome feature dataset; based upon the characterization, generating a therapy model that determines a therapy for correcting the anxiety condition; and at an output device associated with the subject, providing the therapy to the subject with the anxiety condition based upon the characterization and the therapy model.
- 11. A method for at least one of characterizing, diagnosing, and treating an anxiety condition of a subject, the method comprising:
receiving a sample from the subject associated with the anxiety condition; determining nucleic acid sequences of a microorganism component of the sample, comprising: amplifying nucleic acid material of the sample with a primer; determining alignments of the nucleic acid sequences to reference nucleic acid sequences; generating a microbiome feature dataset for the subject based upon the alignments; generating a characterization of the anxiety condition in the subject upon processing the microbiome feature dataset with a characterization model derived from a population of subjects; and at an output device associated with the subject, providing a therapy to the subject with the anxiety condition upon processing the characterization with a therapy model, wherein the therapy comprises a microbiome-modifying therapy operable to improve the anxiety condition in the subject.
