Patent US10201707 AI Biotech/Diagnostics: Cardio

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Aleva Neurotherapeutics

Patent US10201707

Issued 2019-02-12

Treatment Of Autoimmune Diseases With Deep Brain Stimulation

Techniques using electrical stimulation for treating an Autoimmune Disease by means of an implantable pulse generator and at least one electrode. An electrode lead is surgically implanted in a region of the insular cortex to deliver electrical stimulation. The at least one electrode lead and implantable pulse generator contain features that allow the electrical stimulation to be directed to specific volumes of the insular cortex, and ensure that non-therapeutic volumes do not receive electrical stimulation.

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1 Independent Claim

1. A method of treating an autoimmune disorder, comprising: implanting an implantable stimulator into a patient; implanting a lead into the patient, the lead having a MEMS film comprising: a plurality of traces defined in a first metal layer; a first barrier layer disposed on at least a portion of the first metal layer and defining a plurality of through-holes; and a plurality of electrodes defined in a second metal layer, the plurality of electrodes coupled with the plurality of traces through the plurality of through-holes; driving the lead toward a first target area in the patient, wherein the first target area comprises one of a first, a second, a third, or a fourth gyms of an anterior insular cortex; a superior-anterior insula; an inferior-anterior insula; an anterior-anterior insula; a posterior-anterior insula; a large insular gyms of a posterior insula; a superior-posterior insula; or an inferior-posterior insula; generating, by the implantable stimulator, an electrical signal; and delivering the electrical signal to the first target area via at least one of the plurality of electrodes.